CGK 2 Colorimetric Cell-Based ELISA

• Description:

  The CGK 2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CGK 2 protein expression profile in cells. The kit can be used for measuring the relative amounts of CGK 2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CGK 2.

• Synonyms:

  CGMP-dependent protein kinase 2; cGK 2; cGK2;2.7.11.12; cGMP-dependent protein kinase II; cGKII; PRKG2; PRKGR2

• Gene Name:

  PRKG2

• UniProt:

  Q13237

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Highly concentrated in brain, lung and intestinal mucosa.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Crucial regulator of intestinal secretion and bone growth (By similarity) . Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity) . Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity) . Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity) .

• Molecular Weight:

  87432 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  CGMP-dependent protein kinase 2

• Subcellular Location:

  Apical cell membrane; Lipid-anchor.