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CGK 2 Colorimetric Cell-Based ELISA

CAT: 0519-EKC1792Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1792Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The CGK 2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CGK 2 protein expression profile in cells. The kit can be used for measuring the relative amounts of CGK 2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CGK 2.
Synonyms
CGMP-dependent protein kinase 2; cGK 2; cGK2;2.7.11.12; cGMP-dependent protein kinase II; cGKII; PRKG2; PRKGR2
Gene Name
PRKG2
UniProt
Q13237
Reactivity
Human, Mouse, Rat
Tissue Specificity
Highly concentrated in brain, lung and intestinal mucosa.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Crucial regulator of intestinal secretion and bone growth (By similarity) . Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (By similarity) . Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity) . Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity) .
Molecular Weight
87432 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
CGMP-dependent protein kinase 2
Subcellular Location
Apical cell membrane; Lipid-anchor.

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