SHP-1 Colorimetric Cell-Based ELISA Kit

• Description:

  The SHP-1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SHP-1 protein expression profile in cells. The kit can be used for measuring the relative amounts of SHP-1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SHP-1.

• Synonyms:

  Tyrosine-protein phosphatase non-receptor type 6;3.1.3.48; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1; PTPN6; HCP, PTP1C

• Gene Name:

  PTPN6

• UniProt:

  P29350

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

• Molecular Weight:

  67561 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Tyrosine-protein phosphatase non-receptor type 6

• Subcellular Location:

  Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity) . Shuttles between the cytoplasm and nucleus via its association with PDPK1.