EGR1/2 Colorimetric Cell-Based ELISA

• Description:

  The EGR1/2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor EGR1/2 protein expression profile in cells. The kit can be used for measuring the relative amounts of EGR1/2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on EGR1/2.

• Synonyms:

  Early growth response protein 1 ; EGR-1 ; AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225 ; Zinc finger protein Krox-24; EGR1; KROX24, ZNF225

• Gene Name:

  EGR1

• UniProt:

  P18146

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Detected in neutrophils (at protein level) .

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Transcriptional regulator (PubMed:20121949) . Recognizes and binds to the DNA sequence 5'-GCG (T/G) GGGCG-3' (EGR-site) in the promoter region of target genes (By similarity) . Binds double- stranded target DNA, irrespective of the cytosine methylation status (PubMed:25258363, PubMed:25999311) . Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity) .

• Molecular Weight:

  57507 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Early growth response protein 1

• Subcellular Location:

  Nucleus. Cytoplasm.