SHP-2 (Phospho-Tyr542) Colorimetric Cell-Based ELISA Kit

• Description:

  The SHP-2 (Phospho-Tyr542) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor SHP-2 (Phospho-Tyr542) protein expression profile in cells. The kit can be used for measuring the relative amounts of SHP-2 (Phospho-Tyr542) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on SHP-2 (Phospho-Tyr542) .

• Synonyms:

  PTN11; PTP-1D; PTP-2C; PTP2C; PTPN11; Protein-tyrosine phosphatase 2C; Protein-tyrosine phosphatase; non-receptor type 11; SH-PTP2; SH-PTP3; SHPTP2

• Gene Name:

  PTPN11

• UniProt:

  Q06124

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Widely expressed, with highest levels in heart, brain, and skeletal muscle.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573) . Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573) . Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426) .

• Molecular Weight:

  68436 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Tyrosine-protein phosphatase non-receptor type 11

• Subcellular Location:

  Cytoplasm. Nucleus.