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RAD17 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1492Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1492Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The RAD17 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor RAD17 protein expression profile in cells. The kit can be used for measuring the relative amounts of RAD17 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on RAD17.
Synonyms
Cell cycle checkpoint protein RAD17; hRad17; RF-C/activator 1 homolog; RAD17; R24L
Gene Name
RAD17
UniProt
O75943
Reactivity
Human, Mouse
Tissue Specificity
Overexpressed in various cancer cell lines and in colon carcinoma (at protein level) . Isoform 2 and isoform 3 are the most abundant isoforms in non irradiated cells (at protein level) .Ubiquitous at low levels. Highly expressed in testis, where it is expressed within the germinal epithelium of the seminiferous tubuli. Weakly expressed in seminomas (testicular tumors) .
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Essential for sustained cell growth, maintenance of chromosomal stability, and ATR-dependent checkpoint activation upon DNA damage. Has a weak ATPase activity required for binding to chromatin. Participates in the recruitment of the RAD1-RAD9- HUS1 complex and RHNO1 onto chromatin, and in CHEK1 activation. May also serve as a sensor of DNA replication progression, and may be involved in homologous recombination.
Molecular Weight
77055 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Cell cycle checkpoint protein RAD17
Subcellular Location
Nucleus. Phosphorylated form redistributes to discrete nuclear foci upon DNA damage.

UniProtKB · O75943

Cell cycle checkpoint protein RAD17

RAD17_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75943
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RAD17
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hRad17
EC number
—
Processing
—
Secondary accessions
A8K8X2, D3DWA5, O75714, Q7Z3S4, Q9UNK7, Q9UNR7, Q9UNR8, Q9UPF5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleDNA damage

Cellular component

ChromosomeNucleus

PTM

Phosphoprotein

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