ATF7 Colorimetric Cell-Based ELISA Kit

• Description:

  The ATF7 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor ATF7 protein expression profile in cells. The kit can be used for measuring the relative amounts of ATF7 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on ATF7.

• Synonyms:

  ATFA; activating transcription factor 7, cyclic AMP-dependent transcription factor ATF-7

• Gene Name:

  ATF7

• UniProt:

  P17544

• Reactivity:

  Human, Mouse

• Tissue Specificity:

  Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]- 3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.

• Molecular Weight:

  52967 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Cyclic AMP-dependent transcription factor ATF-7

• Subcellular Location:

  Nucleus. Nucleus, nucleoplasm. Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.