WAVE1 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1598Size: 1 Kit - Containing One 96 Well Plate & All Necessary ReagentsDry Ice: NoHazardous: No
CAT#:0519-EKC1598Size:1 Kit - Containing One 96 Well Plate & All Necessary Reagents
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Description
The WAVE1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor WAVE1 protein expression profile in cells. The kit can be used for measuring the relative amounts of WAVE1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on WAVE1.
Synonyms
Wiskott-Aldrich syndrome protein family member 1; WASP family protein member 1; Protein WAVE-1; Verprolin homology domain-containing protein 1; WASF1; KIAA0269, SCAR1, WAVE1
Gene Name
WASF1
UniProt
Q92558
Reactivity
Human, Mouse, Rat
Tissue Specificity
Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity) . As component of the WAVE1 complex, required for BDNF- NTRK2 endocytic trafficking and signaling from early endosomes (By similarity) .
Molecular Weight
61652 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Wiskott-Aldrich syndrome protein family member 1
Subcellular Location
Cytoplasm, cytoskeleton. Cell junction, synapse. Cell junction, focal adhesion. Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas (PubMed:9889097) . Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2 (PubMed:18559503) . In neurons, colocalizes with activated NTRK2 after BDNF addition in endocytic sites through the association with TMEM108 (By similarity) .

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