Smad1 Colorimetric Cell-Based ELISA Kit

• Description:

  The Smad1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Smad1 protein expression profile in cells. The kit can be used for measuring the relative amounts of Smad1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Smad1.

• Synonyms:

  Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; JV4-1; Mad-related protein 1; SMAD family member 1; SMAD 1; Smad1; hSMAD1; Transforming growth factor-beta-signaling protein 1; BSP-1; SMAD1; BSP1, MADH1, MADR1

• Gene Name:

  SMAD1

• UniProt:

  Q15797

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Ubiquitous. Highest expression seen in the heart and skeletal muscle.

• Applications:

  ELISA

• Detection Range:

  > 5000 cells/well

• Function:

  Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) . SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP) -mediated cardiac-specific gene expression.

• Molecular Weight:

  52260 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Mothers against decapentaplegic homolog 1

• Subcellular Location:

  Cytoplasm. Nucleus. Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271) . Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271) . Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity) .