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IkappaB-alpha Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1311Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1311Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The IkappaB-alpha Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor IkappaB-alpha protein expression profile in cells. The kit can be used for measuring the relative amounts of IkappaB-alpha in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on IkappaB-alpha.
Synonyms
I-kappa-B-alpha; IkappaBalpha; IKBA; MAD3; Major histocompatibility complex enhancer-binding protein MAD3; NF-kappaB inhibitor alpha; NFKBI; NFKBIA; RL/IF-1
Gene Name
NFKBIA
UniProt
P25963
Reactivity
Human, Mouse, Rat
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
Molecular Weight
35609 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
NF-kappa-B inhibitor alpha
Subcellular Location
Cytoplasm. Nucleus. Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.

UniProtKB · P25963

NF-kappa-B inhibitor alpha

IKBA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P25963
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NFKBIA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R8L6
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Domain

ANK repeatRepeat

Cellular component

CytoplasmNucleus

Disease

Disease variantEctodermal dysplasia

Biological process

Host-virus interaction

PTM

HydroxylationIsopeptide bondPhosphoproteinUbl conjugation

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