IkappaB-beta Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1312Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No

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CAT#:0519-EKC1312Size:1 Kit, containing one 96 Well Plate and all necessary reagents

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

The IkappaB-beta Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor IkappaB-beta protein expression profile in cells. The kit can be used for measuring the relative amounts of IkappaB-beta in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on IkappaB-beta.

Synonyms

I-kappa-B-beta; IKB-B; IKBB; IkappaBbeta; NF-kappa-BIB; NF-kappaB inhibitor beta; NFKBIB; TR- interacting protein 9; TRIP9; Thyroid receptor interacting protein 9

Gene Name

NFKBIB

UniProt

Q15653

Reactivity

Human, Mouse

Tissue Specificity

Expressed in all tissues examined.

Applications

ELISA

Sample Type

Cell lines

Detection Range

> 5000 cells/well

Function

Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

Molecular Weight

37771 MW

Shipping Conditions

Available

Storage Conditions

Store at 4°C for up to 6 months.

Other Gene Names

NF-kappa-B inhibitor beta

Subcellular Location

Cytoplasm. Nucleus.

UniProtKB · Q15653

NF-kappa-B inhibitor beta

IKBB_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q15653
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: NFKBIB
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: NF-kappa-BIB
EC number: —
Processing: —
Secondary accessions: A8K3F4, Q96BJ7

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Domain

ANK repeatRepeat

Cellular component

CytoplasmNucleus

PTM

Phosphoprotein

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