IkappaB-beta (Phospho-Ser23) Colorimetric Cell-Based ELISA Kit

• Description:

  The IkappaB-beta (Phospho-Ser23) Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor IkappaB-beta (Phospho-Ser23) protein expression profile in cells. The kit can be used for measuring the relative amounts of IkappaB-beta (Phospho-Ser23) in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on IkappaB-beta (Phospho-Ser23) .

• Synonyms:

  I-kappa-B-beta; IKB-B; IKBB; IkappaBbeta; NF-kappa-BIB; NF-kappaB inhibitor beta; NFKBIB; TR- interacting protein 9; TRIP9; Thyroid receptor interacting protein 9

• Gene Name:

  NFKBIB

• UniProt:

  Q15653

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Expressed in all tissues examined.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA- dependent inactivation. Association with inhibitor kappa B- interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.

• Molecular Weight:

  37771 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  NF-kappa-B inhibitor beta

• Subcellular Location:

  Cytoplasm. Nucleus.