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CKI-alpha Colorimetric Cell-Based ELISA

CAT: 0519-EKC1727Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1727Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The CKI-alpha Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CKI-alpha protein expression profile in cells. The kit can be used for measuring the relative amounts of CKI-alpha in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CKI-alpha.
Synonyms
Casein kinase I isoform alpha; CKI-alpha;2.7.11.1; CK1; CSNK1A1
Gene Name
CSNK1A1
UniProt
P48729
Reactivity
Human, Mouse, Rat
Applications
ELISA
Detection Range
> 5000 cells/well
Function
Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis (PubMed:11955436, PubMed:1409656, PubMed:18305108) . May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688) .
Molecular Weight
38915 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Casein kinase I isoform alpha
Subcellular Location
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Nucleus speckle. Cytoplasm, cytoskeleton, cilium basal body. Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton (PubMed:23902688) .

UniProtKB · P48729

Casein kinase I isoform alpha

KC1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P48729
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CSNK1A1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CKI-alpha
EC number
2.7.11.1
Processing
—
Secondary accessions
D3DQG0, D3DQG1, Q4JJA0, Q5U046, Q5U047, Q6FGA2, Q71TU5, Q96HD2, Q9UDK3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleCell divisionMitosisWnt signaling pathway

Cellular component

Cell projectionCentromereChromosomeCytoplasmCytoskeletonKinetochoreNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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