FADD Colorimetric Cell-Based ELISA Kit

• Description:

  The FADD Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor FADD protein expression profile in cells. The kit can be used for measuring the relative amounts of FADD in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on FADD.

• Synonyms:

  FAS-associating death domain-containing protein; Mediator of receptor induced toxicity; MORT1

• Gene Name:

  FADD

• UniProt:

  Q13158

• Reactivity:

  Human

• Tissue Specificity:

  Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.

• Molecular Weight:

  23279 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  FAS-associated death domain protein