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Cullin 2 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1149Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1149Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Cullin 2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Cullin 2 protein expression profile in cells. The kit can be used for measuring the relative amounts of Cullin 2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Cullin 2.
Synonyms
Cullin-2; CUL-2
Gene Name
CUL2
UniProt
Q13617
Reactivity
Human, Mouse
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346) . May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS (VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) .
Molecular Weight
86983 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Cullin-2

UniProtKB · Q13617

Cullin-2

CUL2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13617
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CUL2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CUL-2
EC number
—
Processing
—
Secondary accessions
B3KT95, B7Z6K8, D3DRY6, G3V1S2, O00200, Q5T2B6, Q9UNF9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Host-virus interactionUbl conjugation pathway

Cellular component

Nucleus

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