Caspase 2 Colorimetric Cell-Based ELISA Kit

• Description:

  The Caspase 2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Caspase 2 protein expression profile in cells. The kit can be used for measuring the relative amounts of Caspase 2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Caspase 2.

• Synonyms:

  CASP-2; Caspase-2 precursor; ICH- 1L/1S; ICH-1 protease; ICH1

• Gene Name:

  CASP2

• UniProt:

  P42575

• Reactivity:

  Human

• Tissue Specificity:

  Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321) . Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321) .

• Molecular Weight:

  50685 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Caspase-2