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Caspase 2 Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1085Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1085Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Caspase 2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Caspase 2 protein expression profile in cells. The kit can be used for measuring the relative amounts of Caspase 2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Caspase 2.
Synonyms
CASP-2; Caspase-2 precursor; ICH- 1L/1S; ICH-1 protease; ICH1
Gene Name
CASP2
UniProt
P42575
Reactivity
Human
Tissue Specificity
Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321) . Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321) .
Molecular Weight
50685 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Caspase-2

UniProtKB · P42575

Caspase-2

CASP2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P42575
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CASP2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CASP-2
EC number
3.4.22.55
Processing
Precursor
Secondary accessions
A8K5F9, D3DXD6, E9PDN0, P42576, Q59F21, Q7KZL6, Q86UJ3, Q9BUP7, Q9BZK9, Q9BZL0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinZymogen

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Disease

Disease variantIntellectual disabilityLissencephaly

Molecular function

HydrolaseProteaseThiol protease

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