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CSK Colorimetric Cell-Based ELISA Kit

CAT: 0519-EKC1146Size: 1 Kit, containing one 96 Well Plate and all necessary reagentsDry Ice: NoHazardous: No
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CAT#:0519-EKC1146Size:1 Kit, containing one 96 Well Plate and all necessary reagents
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The CSK Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor CSK protein expression profile in cells. The kit can be used for measuring the relative amounts of CSK in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on CSK.
Synonyms
C-SRC kinase; Protein-tyrosine kinase CYL
Gene Name
CSK
UniProt
P41240
Reactivity
Human, Mouse, Rat
Tissue Specificity
Expressed in lung and macrophages.
Applications
ELISA
Sample Type
Cell lines
Detection Range
> 5000 cells/well
Function
Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T- cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Molecular Weight
50704 MW
Shipping Conditions
Available
Storage Conditions
Store at 4°C for up to 6 months.
Other Gene Names
Tyrosine-protein kinase CSK
Subcellular Location
Cytoplasm. Cell membrane. Mainly cytoplasmic, also present in lipid rafts.

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