Caspase 1 Colorimetric Cell-Based ELISA Kit

• Description:

  The Caspase 1 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Caspase 1 protein expression profile in cells. The kit can be used for measuring the relative amounts of Caspase 1 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Caspase 1.

• Synonyms:

  CASP-1; caspase-1; ICE; IL-1 beta converting enzyme; IL-1BC; IL1BCE; interleukin-1 beta convertase; interleukin-1 beta converting enzyme; p45

• Gene Name:

  CASP1

• UniProt:

  P29466

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs) . Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive (PubMed:28314590) .

• Molecular Weight:

  45159 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Caspase-1

• Subcellular Location:

  Cytoplasm.