Caspase 10 Colorimetric Cell-Based ELISA Kit

• Description:

  The Caspase 10 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Caspase 10 protein expression profile in cells. The kit can be used for measuring the relative amounts of Caspase 10 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Caspase 10.

• Synonyms:

  ALPS2; apoptotic protease Mch-4; CASP-10; CASPA; caspase-10; FADD-like ICE2; FAS-associated death domain protein interleukin-1B-convert

• Gene Name:

  CASP10

• UniProt:

  Q92851-2

• Reactivity:

  Human

• Tissue Specificity:

  Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase- 3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.

• Molecular Weight:

  58951 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Caspase-10