Caspase 9 Colorimetric Cell-Based ELISA Kit

• Description:

  The Caspase 9 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor Caspase 9 protein expression profile in cells. The kit can be used for measuring the relative amounts of Caspase 9 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on Caspase 9.

• Synonyms:

  APAF-3; Apoptotic protease Mch-6; Apoptotic protease activating factor 3; CASP-9; Caspase-9; Caspase-9 precursor; Caspase9; ICE-LAP6; ICE-like apoptotic protease 6; MCH6; RNCASP9

• Gene Name:

  CASP9

• UniProt:

  P55211

• Reactivity:

  Human, Mouse, Rat

• Tissue Specificity:

  Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly (ADP- ribose) polymerase (PARP) .

• Molecular Weight:

  46281 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Caspase-9