AP-2 Colorimetric Cell-Based ELISA Kit

• Description:

  The AP-2 Cell-Based ELISA Kit is a convenient, lysate-free, high throughput and sensitive assay kit that can monitor AP-2 protein expression profile in cells. The kit can be used for measuring the relative amounts of AP-2 in cultured cells as well as screening for the effects that various treatments, inhibitors (ie. siRNA or chemicals), or activators have on AP-2.

• Synonyms:

  AP-2; AP-2 transcription factor; AP2A; AP2TF; TFAP2; TFAP2A; activating enhancer-binding protein 2 alpha; activator protein 2

• Gene Name:

  TFAP2A

• UniProt:

  P05549

• Reactivity:

  Human, Mouse, Rat

• Applications:

  ELISA

• Sample Type:

  Cell lines

• Detection Range:

  > 5000 cells/well

• Function:

  Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.

• Molecular Weight:

  48062 MW

• Shipping Conditions:

  Available

• Storage Conditions:

  Store at 4°C for up to 6 months.

• Other Gene Names:

  Transcription factor AP-2-alpha

• Subcellular Location:

  Nucleus.