NF-κΒ activator 1

• Description :

  NF-κΒ activator 1 (compound 32) is a potent NF-κΒ activator with an EC50 of 0.9 μM. NF-κΒ activator 1 induces superoxide dismutase (SOD) 2 mRNA expression[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319

• Target :

  NF-κB

• Type :

  Reference compound

• Related Pathways :

  NF-κB

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/nf-κ-activator-1.html

• Purity :

  99.59

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(O)C1=CC=CC(C2=CSC(NC3=CC=CC=C3F)=N2)=C1

• Molecular Formula :

  C16H11FN2O2S

• Molecular Weight :

  314.33

• Precautions :

  H302, H315, H319

• References & Citations :

  [1]Mathew B, et al. Structure-activity relationship (SAR) studies of N- (3-methylpyridin-2-yl) -4- (pyridin-2-yl) thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS [published online ahead of print, 2020 Oct 22]. Eur J Med Chem. 2020;112952.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NF-κB

• CAS Number :

  [2387524-59-4]