NF-κΒ activator 1

CAT: 0804-HY-134476-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-134476-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

NF-κΒ activator 1 (compound 32) is a potent NF-κΒ activator with an EC50 of 0.9 μM. NF-κΒ activator 1 induces superoxide dismutase (SOD) 2 mRNA expression[1].

CAS Number

2387524-59-4

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

NF-κB

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nf-κ-activator-1.html

Purity

99.59

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C1=CC=CC(C2=CSC(NC3=CC=CC=C3F)=N2)=C1

Molecular Formula

C16H11FN2O2S

Molecular Weight

314.33

Precautions

H302, H315, H319

References & Citations

[1]Mathew B, et al. Structure-activity relationship (SAR) studies of N- (3-methylpyridin-2-yl) -4- (pyridin-2-yl) thiazol-2-amine (SRI-22819) as NF-ҡB activators for the treatment of ALS [published online ahead of print, 2020 Oct 22]. Eur J Med Chem. 2020;112952.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

NF-κB

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