TRAP-14 amide

CAT: 0804-HY-P5764Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P5764Size:1 Each
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Description
TRAP-14 amide, a proteinase activated receptor (PAR) -activating peptide, is a PAR agonist with an EC50 of 24 μM. TRAP-14 amide significantly induces platelet aggregation through ADP- and MMP-2-dependent pathways with Aspirin (HY-14654) -insensitivity. TRAP-14 amide also effectively increases glycoprotein (GP) Ib and GPIIb/IIIa surface expression and ADP release[1].
CAS Number
[141923-36-6]
UNSPSC
12352209
Target
Integrin; MMP; Protease Activated Receptor (PAR)
Related Pathways
Cytoskeleton; GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
OC[C@H](N)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(N)=O)C(N2[C@@H](CCC2)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@H](C(N[C@@H](CCC(O)=O)C(N3[C@@H](CCC3)C(N[C@H](C(N)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=C(C=C5)O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Molecular Formula
C81H119N21O22
Molecular Weight
1738.94
References & Citations
[1]Chung AW, et al. Mechanisms of action of proteinase-activated receptor agonists on human platelets. Br J Pharmacol. 2002 Mar;135 (5) :1123-32. |[2]Chung AW, et al. Mechanisms of action of proteinase-activated receptor agonists on human platelets. Br J Pharmacol. 2002 Mar;135 (5) :1123-32.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
MMP-2; αIIbβ3

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