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KG-548

CAT: 0804-HY-120087-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120087-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KG-548 is an ARNT/TACC3 disruptor and a HIF-1α inhibitor. KG-548 directly interferes with ARNT/TACC3 complex formation by competing with TACC3 for binding to the ARNT PAS-B domain. ARNT is the aryl hydrocarbon receptor nuclear translocator, also known as HIF-β[1][2].
CAS Number
175205-09-1
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kg-548.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C1=CC(C(F)(F)F)=CC(C2=NN=NN2)=C1)(F)F
Molecular Formula
C9H4F6N4
Molecular Weight
282.15
Precautions
H228, H315, H319
References & Citations
[1]Guo Y, et al. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. ACS Chem Biol. 2013 Mar 15;8 (3) :626-35. |[2]Kleszcz R, et al. The inhibition of c-MYC transcription factor modulates the expression of glycolytic and glutaminolytic enzymes in FaDu hypopharyngeal carcinoma cells. Adv Clin Exp Med. 2018 Jun;27 (6) :735-742.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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