22-HDHA

• Description:

  22-HDHA (22-Hydroxy Docosahexaenoic acid) is an oxidation product of docosahexaenoic acid. In vitro, it is formed upon incubation of rat liver microsomes with DHA and NADPH and also by the human cytochrome P450 (CYP) isoform CYP4F3B in BTI-TN-5B1-4 microsomes. Serum levels of 22-HDHA increase following dietary DHA supplementation in humans.

• Product Name Alternative:

  22-Hydroxy Docosahexaenoic acid; 22-OH DHA

• UNSPSC:

  12352211

• Hazard Statement:

  H225-H319-H336

• Target:

  Cytochrome P450

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/22-hdha.html

• Smiles:

  OCC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O

• Molecular Formula:

  C22H32O3

• Molecular Weight:

  344.49

• Precautions:

  P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501

• References & Citations:

  [1]VanRollins, et al. Oxidation of docosahexaenoic acid by rat liver microsomes. J. Biol. Chem. 259 (9), 5776-5783 (1984) .

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [90780-46-4]