17-HDHA

• Description:

  17-HDHA is a DHA-derived specialized proresolving mediator (SPM) . 17-HDHA enhances the antibody-mediated immune response against influenza virus. 17-HDHA enhances the differentiation of B cells toward the CD27+ CD38+ antibody-secreting cell phenotype, thereby strongly increasing IgM and IgG production by activated B cells[1][2].

• UNSPSC:

  12352211

• Hazard Statement:

  H225, H319

• Target:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/17-hdha.html

• Concentration:

  290.28 μM * 500 μL in Ethanol

• Purity:

  98.8

• Solubility:

  10 mM in DMSO

• Smiles:

  CC/C=C\CC(O)/C=C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O

• Molecular Formula:

  C22H32O3

• Molecular Weight:

  344.49

• Precautions:

  H225, H319

• References & Citations:

  [1]Ramon S, et al. The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant? J Immunol. 2014 Dec 15;193 (12) :6031-40.|[2]Ramon S, et al. Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells. J Immunol. 2012 Jul 15;189 (2) :1036-42.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Solution, -20°C, 2 years

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [90780-52-2]