N3-PEG3-CH2CH2COOH
CAT:
804-HY-42490-02
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
N3-PEG3-CH2CH2COOH
- CAS Number: 1056024-94-2
- UNSPSC Description: N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Target Antigen: ADC Linker; PROTAC Linkers
- Type: ADC Related
- Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
- Applications: COVID-19-immunoregulation
- Field of Research: Cancer; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/n3-peg3-ch2ch2cooh.html
- Purity: 98.0
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(O)CCOCCOCCOCCN=[N+]=[N-]
- Molecular Weight: 247.25
- References & Citations: [1]Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C (Powder, protect from light)
- Clinical Information: No Development Reported