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LCL-PEG3-N3

CAT: 0804-HY-139999Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-139999Size:1 Each
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Description
LCL-PEG3-N3 is a decoy oligonucleotide ligand for E3 ligase which can be used for developing chimeric molecules LCL-ER (dec), degrading the estrogen receptor[1]. LCL-PEG3-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
CAS Number
3033849-90-7
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lcl-peg3-n3.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(OCCOCCOCCN=[N+]=[N-])=CC=C1)C2=CSC([C@H]3N(C([C@H](C4CCCCC4)NC([C@H](C)NC)=O)=O)CCC3)=N2
Molecular Formula
C32H45N7O6S
Molecular Weight
655.81
References & Citations
[1]Miyako Naganuma, et al. Development of Chimeric Molecules That Degrade the Estrogen Receptor Using Decoy Oligonucleotide Ligands. ACS Med Chem Lett. 2022;13 (1) :134-139.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IAP

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