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Cyclic L27-11

CAT: 0804-HY-P10548Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P10548Size:1 Each
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Description
Cyclic L27-11 is a cyclic peptide-like antibiotic with strong antibacterial activity against specific bacteria such as Pseudomonas sp. Cyclic L27-11 shows nanomolar antibacterial activity against Pseudomonas sp., especially Pseudomonas aeruginosa. Cyclic L27-11 interferes with the function of bacterial outer membrane protein LptD, preventing the normal transport of lipopolysaccharide (LPS), leading to the accumulation of membrane-like substances in bacterial cells, which in turn affects the survival of bacteria. Cyclic L27-11 can be used in the development of antibacterial agents[1].
CAS Number
1221423-80-8
UNSPSC
12352209
Target
Bacterial
Type
Peptides
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/cyclic-l27-11.html
Smiles
O=C1N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@@H](C(N3[C@H](C(N[C@H]1[C@@H](C)O)=O)CCC3)=O)CCC2)=O)CCCCN)=O)C)=O)CCCCN)=O)CCCCN)=O)CC4=CNC5=CC=CC=C45)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CC(C)C)=O)CC6=CNC7=CC=CC=C67
Molecular Formula
C87H141N27O15
Molecular Weight
1805.22
References & Citations
[1]Schmidt J, et al. Structural studies of β-hairpin peptidomimetic antibiotics that target LptD in Pseudomonas sp[J]. Bioorganic & medicinal chemistry, 2013, 21 (18) : 5806-5810.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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