Cyclic GMP

Cyclic GMP

• CAS Number: 7665-99-8
• UNSPSC Description: Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators[1][2].
• Target Antigen: Endogenous Metabolite; STING
• Type: Natural Products
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cyclic-gmp.html
• Purity: 99.43
• Solubility: H2O : 5.83 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O[C@@H]([C@H](N1C=NC2=C1N=C(N)NC2=O)O[C@@H]3CO4)[C@@H]3OP4(O)=O
• Molecular Weight: 345.21
• References & Citations: [1]Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30.|[2]Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C, 3 years (Powder)
• Clinical Information: No Development Reported