Cyclic GMP

CAT: 0804-HY-113469-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-113469-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Cyclic GMP (cGMP), an important second messenger, is a major intracellular mediator of extracellular signals such as nitric oxide (NO) and natriuretic peptides (NPs) . Effects of Cyclic GMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation channels, and PDEs. Cyclic GMP can inhibit both platelet adhesion and aggregation. cGAMP (Cyclic-GMP-AMP) (HY-12512), a conjugate of Cyclic GMP and AMP, can induce IRF3 phosphorylation and nuclear translocation, enhancing antiviral immune responses[1][2][3][4].
CAS Number
[7665-99-8]
Product Name Alternative
ALKS 8700; BIIB098
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/cyclic-gmp.html
Purity
99.77
Solubility
H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O[C@@H]([C@H](N1C=NC2=C1N=C(N)NC2=O)O[C@@H]3CO4)[C@@H]3OP4(O)=O
Molecular Formula
C10H12N5O7P
Molecular Weight
345.21
Precautions
H315, H319, H335
References & Citations
[1]Francis SH, et al. cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev. 2010 Sep;62 (3) :525-63.|[2]Friebe A, et al. cGMP: a unique 2nd messenger molecule - recent developments in cGMP research and development. Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb;393 (2) :287-302.|[3]Hartzell HC, et al. Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells. Nature. 1986 Sep 18-24;323 (6085) :273-5.|[4]Chintala MS, et al. Cyclic GMP but not cyclic AMP prevents renal platelet accumulation after ischemia-reperfusion in anesthetized rats. J Pharmacol Exp Ther. 1994 Dec;271 (3) :1203-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

Related Products

CatalogName
HY-107780Cyclic-di-GMP
HY-107780B-01Cyclic-di-GMP (diammonium)
HY-110382-01Cyclic-di-GMP (disodium)
HY-107780ACyclic-di-GMP (sodium)
HY-110382S13C20,15N10-Cyclic di-GMP (sodium)
HY-107632GGYY4137 (GMP)
HY-13506G-01M344 (GMP)
HY-15682G-01TTNPB (GMP)
HY-B1505GAcefylline (GMP)
HY-101570GNedisertib (GMP)

Alternative Products

CatalogName
MBS621824-01Cyclic Adenosine Monophosphate (Cyclic AMP)
C8450-12ACyclic Adenosine Monophosphate (Cyclic AMP) discontinued
139963CAMP (Cyclic Adenosine Monophosphate, Cyclic AMP)
M18885-01Cyclic AMP
TP3053-01Cyclic (YCDGFYACYMDV)
TP3648-01Cyclic AC253
MBS3612193-01Cyclic somatostatin
TN9056-01Cyclic GMP
MBS5801533Cyclic MKEY
M30200-01CTTHWGFTLC, CYCLIC

Popular Products