Cyclic GMP
CAT:
804-HY-113469-03
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Cyclic GMP
- CAS Number: 7665-99-8
- UNSPSC Description: Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators[1][2].
- Target Antigen: Endogenous Metabolite; STING
- Type: Natural Products
- Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/cyclic-gmp.html
- Purity: 99.43
- Solubility: H2O : 5.83 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O[C@@H]([C@H](N1C=NC2=C1N=C(N)NC2=O)O[C@@H]3CO4)[C@@H]3OP4(O)=O
- Molecular Weight: 345.21
- References & Citations: [1]Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30.|[2]Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C, 3 years (Powder)
- Clinical Information: No Development Reported