Cyclic GMP

• Product Name Alternative:

  ALKS 8700; BIIB098

• UNSPSC Description:

  Cyclic GMP (cGAMP) is an endogenous second messenger that triggers interferon production in response to cytoplasmic DNA. Cyclic GMP activates the stimulator of interferon genes (STING), activating a signaling cascade that leads to the production of type I interferons and other immune mediators[1][2].

• Target Antigen:

  Endogenous Metabolite; STING

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cyclic-gmp.html

• Purity:

  99.43

• Solubility:

  H2O : 5.83 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O[C@@H]([C@H](N1C=NC2=C1N=C(N)NC2=O)O[C@@H]3CO4)[C@@H]3OP4(O)=O

• Molecular Weight:

  345.21

• References & Citations:

  [1]Wu J, et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. 2013 Feb 15;339(6121):826-30.|[2]Ablasser A, et al. Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP. Nature. 2013 Nov 28;503(7477):530-4.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C, 3 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  7665-99-8