Cyclic MKEY

Cyclic MKEY

• UNSPSC Description: Cyclic MKEY is a synthetic cyclic peptide inhibitor of CXCL4-CCL5 heterodimer formation, which protects against atherosclerosis and aortic aneurysm formation by mediating inflammation. Cyclic MKEY also protects against stroke-induced brain injury in mice[1][2].
• Target Antigen: CXCR
• Type: Peptides
• Related Pathways: GPCR/G Protein;Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/cyclic-mkey.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC3=CC=C(C=C3)O)C(N[C@@H]([C@H](O)C)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC(C)C)C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC4=CC=CC=C4)C(N[C@@H](C(C)C)C(N[C@@H]([C@H](O)C)C(N[C@H]5CCCNC(N)=N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(O)=O)NC5=O)N
• Molecular Weight: 2530.87
• References & Citations: [1]Fan Y,et al. MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice. J Am Heart Assoc. 2016 Sep 15;5(9). pii: e003615.|[2]Iida Y, et al. Peptide inhibitor of CXCL4-CCL5 heterodimer formation, MKEY, inhibits experimental aortic aneurysm initiation and progression. Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):718-26.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported