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Cyclic somatostatin

CAT: 0804-HY-P0084-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0084-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease[1][2][3].
CAS Number
38916-34-6
Product Name Alternative
SRIF-14; Somatostatin-14
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Cyclic-somatostatin.html
Purity
99.87
Solubility
DMF : 100 mg/mL (ultrasonic) |DMSO : ≥ 50 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
O=C([C@@H](N)C)NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CO)=O)[C@@H](C)O)=O)CC2=CC=CC=C2)=O)[C@@H](C)O)=O)CCCCN)=O)CC3=CNC4=CC=CC=C34)=O)CC5=CC=CC=C5)=O)CC6=CC=CC=C6)=O)CC(N)=O)=O)CCCCN)=O)CSSC[C@H](NC1=O)C(O)=O)=O
Molecular Formula
C76H104N18O19S2
Molecular Weight
1637.88
Precautions
H302, H315, H319, H335
References & Citations
[1]Murray F, et al. Positive and negative contractile effects of somatostatin-14 on rat ventricular cardiomyocytes. J Cardiovasc Pharmacol. 2001 Mar;37 (3) :324-32.|[2]Bell D, et al. SRIF receptor subtype expression and involvement in positive and negative contractile effects of somatostatin-14 (SRIF-14) in ventricular cardiomyocytes. Cell Physiol Biochem. 2008;22 (5-6) :653-64.|[3]https://pubmed.ncbi.nlm.nih.gov/9374319/
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
Launched

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