Cyclic HPMPC

• Description:

  Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain) -infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model[1][2].

• UNSPSC:

  12352005

• Target:

  CMV; Orthopoxvirus

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/cyclic-hpmpc.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(C=CC(N)=N1)C[C@H](OC2)CO[P]2(O)=O

• Molecular Formula:

  C8H12N3O5P

• Molecular Weight:

  261.17

• References & Citations:

  [1]Smee DF, et al. Effects of four antiviral substances on lethal vaccinia virus (IHD strain) respiratory infections in mice. Int J Antimicrob Agents. 2004;23 (5) :430-437.|[2]Bravo FJ, et al. Effect of maternal treatment with cyclic HPMPC in the guinea pig model of congenital cytomegalovirus infection. J Infect Dis. 2006;193 (4) :591-597.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  [127757-45-3]