ERα degrader 8

ERα degrader 8

• CAS Number: 2971837-95-1
• UNSPSC Description: ERα degrader 8 (Compound 18j) is a selective Estrogen Receptor degrader. ERα degrader 8 is degrader to MCF-7 cells with IC50 value of 0.15 μM[1].
• Target Antigen: Estrogen Receptor/ERR
• Type: Reference compound
• Related Pathways: Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/erα-degrader-8.html
• Solubility: 10 mM in DMSO
• Smiles: OC(/C=C/C(C=C1)=CC=C1OC2=C(C(C3=CC=CC=C3CC)=O)C=NC4=CC(O)=CC=C42)=O
• Molecular Weight: 439.46
• References & Citations: [1]Lu Y, et al. Discovery of novel quinoline scaffold selective estrogen receptor degraders (SERDs) for treatment of ER positive breast cancer with enhanced antiproliferative bioactivity through immunogenic cell death (ICD) effects. European Journal of Medicinal Chemistry, 2024: 116534.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported