HDAC6 degrader-1

HDAC6 degrader-1

• CAS Number: 2439058-23-6
• UNSPSC Description: HDAC6 degrader-1 is a PROTAC that comprises a selective HDAC6 inhibitor Nexturastat A (Nex A) as the HDAC6 binder, a linker and a ligand for recruiting E3 ligase. HDAC6 degrader-1 induces significant degradation of HDAC6, exhibits excellent selectivity against other HDACs, and demonstrates efficient inhibition of cell proliferation[1].
• Target Antigen: PROTACs
• Type: Reference compound
• Related Pathways: PROTAC
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/hdac6-degrader-1.html
• Smiles: O=C(C1=CC=C(CN(CCCCC2=CN(CCOCCOCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)N=N2)C(NC6=CC=CC=C6)=O)C=C1)NO
• Molecular Weight: 795.84
• References & Citations: [1]An Z, et al. Developing potent PROTACs tools for selective degradation of HDAC6 protein [published correction appears in Protein Cell. 2019 Feb 22;:]. Protein Cell. 2019;10(8):606-609.
• Shipping Conditions: Room Temperature