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KRN383 analog

CAT: 0804-HY-123201Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123201Size:1 Each
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Description
KRN383 analog is an analog of KRN383. KRN383 is an orally active Flt3 inhibitor that inhibits the autophosphorylation of Flt3 bearing internal tandem duplications (ITDs) and the Asp835Tyr (D835Y) point mutation with IC50 values of IC50 values of [1].
CAS Number
919767-02-5
UNSPSC
12352005
Target
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/krn383-analog.html
Smiles
O=C(NC1=CCC(C=C1)OC2=CC=NC3=CC(O)=C(C=C23)OC)N
Molecular Formula
C17H17N3O4
Molecular Weight
327.33
References & Citations
[1]Nishiyama U, et al. Antineoplastic effect of a single oral dose of the novel Flt3 inhibitor KRN383 on xenografted human leukemic cells harboring Flt3-activating mutations. Leuk Res. 2006 Dec;30 (12) :1541-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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