SR33805 (analog)

CAT: 0804-HY-121701Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-121701Size:1 Each
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Description
SR 33805 (analog) is an orally active Ca2+ channel blocker that selectively inhibits the proliferation of smooth muscle cells. SR 33805 (analog) reduces calcium uptake by blocking calcium channels, thereby inhibiting smooth muscle cell proliferation induced by serum, platelet-derived growth factor, and basic fibroblast growth factor. SR 33805 (analog) significantly reduces intimal thickening following endothelial injury in rabbits. SR 33805 (analog) shows promise for cardiovascular disease research, such as in early atherosclerosis[1].
CAS Number
[121346-32-5]
UNSPSC
12352005
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sr33805-analog.html
Smiles
O=S(C1=CC=C(C=C1)OCCCN(CCC2=CC=C(C(OC)=C2)OC)C)(C(N3C)=C(C4=C3C=CC=C4)C(C)C)=O
Molecular Formula
C32H40N2O5S
Molecular Weight
564.74
References & Citations
[1]Dol F, et al. Effect of SR 33805 on arterial smooth muscle cell proliferation and neointima formation following vascular injury. Eur J Pharmacol. 1995 Jul 4;280 (2) :135-42.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1

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