SR33805 (analog)

• Description :

  SR 33805 (analog) is an orally active Ca2+ channel blocker that selectively inhibits the proliferation of smooth muscle cells. SR 33805 (analog) reduces calcium uptake by blocking calcium channels, thereby inhibiting smooth muscle cell proliferation induced by serum, platelet-derived growth factor, and basic fibroblast growth factor. SR 33805 (analog) significantly reduces intimal thickening following endothelial injury in rabbits. SR 33805 (analog) shows promise for cardiovascular disease research, such as in early atherosclerosis[1].

• UNSPSC :

  12352005

• Target :

  Calcium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/sr33805-analog.html

• Smiles :

  O=S(C1=CC=C(C=C1)OCCCN(CCC2=CC=C(C(OC)=C2)OC)C)(C(N3C)=C(C4=C3C=CC=C4)C(C)C)=O

• Molecular Formula :

  C32H40N2O5S

• Molecular Weight :

  564.74

• References & Citations :

  [1]Dol F, et al. Effect of SR 33805 on arterial smooth muscle cell proliferation and neointima formation following vascular injury. Eur J Pharmacol. 1995 Jul 4;280 (2) :135-42.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1

• CAS Number :

  [121346-32-5]