Alectinib analog

Alectinib analog

• CAS Number: 1256577-71-5
• UNSPSC Description: Alectinib analog (CH5424802 analog) is a selective ALK inhibitor with activity in blocking resistance gating mutations. The synthetic optimization of alectinib analog allows it to be combined with specific peptides to improve the ability to target cancer cells. Alectinib analog exhibits low micromolar IC50 values in antiproliferation and shows good cytotoxic effects. The inhibitory activity of alectinib analog is closely related to its stability and release of active ingredients. Alectinib analog demonstrated the ability to inhibit vascular septal length or width in an in vivo zebrafish model[1].
• Target Antigen: Anaplastic lymphoma kinase (ALK)
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/alectinib-analog.html
• Smiles: N#CC1=CC(NC2=C3C(C4=CC=C(N5CCC(CC5)N6CCOCC6)C=C4C2(C)C)=O)=C3C=C1
• Molecular Weight: 454.56
• References & Citations: [1]Synthesis and Anti-Angiogenic Activity of Novel c(RGDyK) Peptide-Based JH-VII-139-1 Conjugates
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported