Apoptotic agent-4

• Description :

  Apoptotic agent-4 (Compound 9) is a apoptosis inducer. Apoptotic agent-4 inhibits VEGFR-2 with an IC50 of 0.5717 μM. Apoptotic agent-4 inhibits cancer cell proliferation and arrests the cell at both the G2/M and Pre-G1 phases[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; VEGFR

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/apoptotic-agent-4.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1CCN(S(=O)(C2=CC=C(/C(C)=N/NC(NC3=CC=C(OC)C=C3)=S)C=C2)=O)CC1

• Molecular Formula :

  C22H28N4O3S2

• Molecular Weight :

  460.61

• References & Citations :

  [1]Elgammal WE, et al. Design, synthesis, and anticancer evaluation of N-sulfonylpiperidines as potential VEGFR-2 inhibitors, apoptotic inducers. Bioorg Chem. 2024 Apr;145:107157.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  VEGFR2/KDR/Flk-1