Apoptotic agent-4

• UNSPSC Description:

  Apoptotic agent-4 (Compound 9) is a apoptosis inducer. Apoptotic agent-4 inhibits VEGFR-2 with an IC50 of 0.5717 μM. Apoptotic agent-4 inhibits cancer cell proliferation and arrests the cell at both the G2/M and Pre-G1 phases[1].

• Target Antigen:

  Apoptosis; VEGFR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/apoptotic-agent-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1CCN(S(=O)(C2=CC=C(/C(C)=N/NC(NC3=CC=C(OC)C=C3)=S)C=C2)=O)CC1

• Molecular Weight:

  460.61

• References & Citations:

  [1]Elgammal WE, et al. Design, synthesis, and anticancer evaluation of N-sulfonylpiperidines as potential VEGFR-2 inhibitors, apoptotic inducers. Bioorg Chem. 2024 Apr;145:107157.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported