HC-056456

• Description :

  HC-056456 is an effective but not perfectly-selective blocker of CatSper channels. The [Na+]i rise is slowed by HC-056456 (IC50~3 µM) .

• CAS Number :

  [7733-96-2]

• Product Name Alternative :

  3,4-Bis (2-thienoyl) -1,2,5-oxadiazole-N-oxide

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Calcium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/HC-056456.html

• Purity :

  98.00

• Solubility :

  DMSO : 125 mg/mL (ultrasonic)

• Smiles :

  [O-][N+]1=C(C(C2=CC=CS2)=O)C(C(C3=CC=CS3)=O)=NO1

• Molecular Formula :

  C12H6N2O4S2

• Molecular Weight :

  306.32

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Carlson AE, et al. Pharmacological targeting of native CatSper channels reveals a required role in maintenance of sperm hyperactivation. PLoS One. 2009 Aug 31;4 (8) :e6844.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported