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RecombinantFGF-21, Mouse

CAT: 0384-BK0041-01Size: 10 µgDry Ice: NoHazardous: No
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CAT#:0384-BK0041-01Size:10 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Fibroblast growth factor-21 (FGF21) belongs to the large FGF family which has at least 23 members. Along with FGF-19/15 and FGF-23, FGF-21 is categorized as a member of the atypical FGF subfamily, as it must be complexed to the Klotho co-receptor in order to bind to the FGF receptors and activate the downstream signaling pathway. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. Recombinant Mouse Fibroblast Growth Factor-21 (FGF-21) produced in E.coli is a single non-glycosylated polypeptide chain containing 182 amino acids. A fully biologically active molecule, rmFGF-21 has a molecular mass of 19.9 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
CAS Number
9000-83-3
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 97% as analyzed by SDS-PAGE& HPLC.
Bioactivity
ED50 < 0.5 μg/ml, measured by a cell proliferation assay using NIH-3T3 cells in the presence of 1.25 µg/mL mouse Klotho and 10 µg/mL heparin, corresponding to a specific activity of > 2 x 10ˆ3 units/mg.
Reconstitution
Reconstituted in ddH2O or PBS at 100 μg/ml.
Molecular Weight
19.9 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant Mouse Fibroblast Growth Factor-21 (FGF-21), remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Mouse FGF-21 should be stable up to 1 week at 4°C or up to 3 months at -20°C.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized after extensive dialysis against PBS.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
AYP IPDSSPLLQF GGQVRQRYLY TDDDQDTEAH LEIREDGTVV GAAHRSPESL LELKALKPGV IQILGVKASR FLCQQPDGAL YGSPHFDPEA CSFRELLLED GYNVYQSEAH GLPLRLPQKD SPNQDATSWG PVRFLPMPGL LHEPQDQAGF LPPEPPDVGS SDPLSMVEPL QGRSPSYAS

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