RegisterLogin

CD357 polyclonal antibody

CAT: 0384-NCP0306P-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-NCP0306P-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
TNFRSF18, also known as glucocorticoid-induced tumor necrosis factor-receptor (TNFR) -related protein (GITR) and activation-inducible TNFR family receptor, encodes a type 1 membrane protein of the TNF-receptor superfamily. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. GITR is an immune cell co-stimulatory receptor expressed constitutively at high levels on CD4+CD25+ T regulatory cells (Tregs), at low levels on naïve and memory T cells, and is induced upon T cell activation. Studies show GITR can also be induced on NK cells, macrophages, and DCs. Although GITR does not have intrinsic enzymatic activity, TNFSF18 (also known as GITRL) expressed on antigen presenting cells binds to GITR, resulting in recruitment of TNFR-associated factor family members and activation of the NF-κB pathway in T cells. GITR ligation has been shown to play a role in CD8+ T cell activation, cytotoxicity, and memory T cell survival. In the thymus, GITR is thought to play a key role in dominant immunological self-tolerance through thymic Treg differentiation and expansion. Of note, GITR ligation inhibits Treg suppressive function and promotes effector T cell resistance to Treg suppression. Due to the combined effects on both Treg suppression and effector cell activation, GITR represents a unique opportunity for immunotherapeutic intervention in cancer.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Tumor necrosis factor receptor superfamily member 18; Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein; CD357; TNFRSF18; AITR; GITR
Swiss Prot
Q9Y5U5
Reactivity
Human
Immunogen
Recombinant protein of human CD357.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:5000~1:10000 IF 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 24 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD357 polyclonal antibody detects endogenous levels of CD357 protein.
Applications Notes
Western blot (WB) analysis of CD357 polyclonal antibody at 1:6000 dilution Lane1:A549 whole cell lysate (30ug) Lane2:SGC7901 whole cell lysate (30ug)
Host or Source
Rabbit

Related Products

CatalogName
NCP0306-01CD357 Recombinant Protein
NCP0356P-01CD317 polyclonal antibody
NCP0302P-01CD352 polyclonal antibody
NCP0307P-01CD358 polyclonal antibody
NCP0297P-01CD337 polyclonal antibody
BS62551-01CD354 polyclonal antibody
NCP0328P-01CD327 polyclonal antibody
NCP0203P-01CD37 polyclonal antibody
BS9214CD307 (Y319) polyclonal antibody
BZ16794-01Polyclonal antibodyPN1 polyclonal antibody

Alternative Products

CatalogName
E43CP0306PCD357 polyclonal antibody
GWB-E2D5F4Mouse CD357 Antibody
76-984CD357 Antibody [DTA-1]
MO357F(V25)Anti-GiTR (CD357) antibody
abx200778-01GiTR (CD357) Antibody (FITC)
GWB-5B3ACAMouse CD357 Antibody (RPE)
E55A06123Human CD357/TNFRSF18/GITR Antibody
76-987CD357 Antibody [DTA-1] (PE)
MBS4381365-01CD357/GITR
E43CP0306CD357 Recombinant Protein

Popular Products