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CD317 polyclonal antibody

CAT: 0384-NCP0356P-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-NCP0356P-01Size:50 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
BST2 (CD317, Tetherin, HM1.24) is a type II transmembrane glycoprotein functioning as a major mediator of the innate immune defense against the dissemination of enveloped viruses by tethering virion on the cell surface. BST2 has an N-terminal cytoplasmic tail for endocytosis and cytoskeletal signaling, a transmembrane domain, an extracellular domain containing putative disulfide bonds and coiled coil region for forming homodimer, and a C-terminal GPI domain for membrane anchoring. Both the transmembrane domain and the GPI domain can insert either to the cell membrane or the viral envelope membrane and hold them together to prevent viral release. Some viruses encode proteins, such as HIV-1 and Vpu respectively, to act as antagonists to counteract BST2. BST2 is overexpressed in gastrointestinal cancers, breast cancer, lung cancer, and multiple myeloma. BST2 monoclonal antibody targeting myeloma or lung cancer cells induces cellular cytotoxicity and cell death (ADCC, antibody-dependent cell-mediated cytotoxicity) . Thus, BST2 serves as a potential target for tumor immunotherapy.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Bone marrow stromal antigen 2; BST-2; HM1.24 antigen; Tetherin; CD317; BST2
Swiss Prot
Q10589
Reactivity
Human, Mouse
Immunogen
Recombinant protein of human CD317.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:5000~1:10000 IF: 1:100~1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 30/60 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD317 polyclonal antibody detects endogenous levels of CD317 protein.
Applications Notes
Western blot (WB) analysis of CD317 polyclonal antibody at 1:5000 dilution Lane1:The Kidney tissue lysate of Mouse (30ug) Lane2:L02 cell membrane lysate (24ug)
Host or Source
Rabbit

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