CD37 polyclonal antibody

• Background:

  CD37 belongs to the tetraspanin family of transmembrane proteins and a high level of expression is restricted largely to normal and as well as malignant B cells. Other immune cell populations such as T cells and monocytes, however, have been shown to express low levels of CD37. While the molecular mechanisms are still not fully resolved, research studies have shown that CD37 becomes tyrosine phosphorylated and facilitates association with intracellular signaling proteins that drive both survival and apoptosis in B cells. Due to its fairly restricted, high level of expression in normal and neoplastic B cells, CD37 has become an attractive immunotherapy target in the context of B cells malignancies.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.

• Product Name Alternative:

  Leukocyte antigen CD37; Tetraspanin-26; Tspan-26; CD37; TSPAN26

• Swiss Prot:

  P11049

• Reactivity:

  Human

• Immunogen:

  Recombinant protein of human CD37.

• Conjugation:

  Unconjugated

• Applications:

  WB IF

• Dilution:

  WB: 1:2000~1:5000 IF 1:50~1:200

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodified

• Molecular Weight:

  ~ 43 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CD37 polyclonal antibody detects endogenous levels of CD37 protein.

• Applications Notes:

  Western blot (WB) analysis of CD37 polyclonal antibody at 1:2000 dilution Lane1:A549 whole cell lysate (30ug) Lane2:EC9706 cell membrane lysate (24ug)

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4