CD358 polyclonal antibody

CAT: 0384-NCP0307P-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-NCP0307P-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Plays a role in neuronal apoptosis, including apoptosis in response to amyloid peptides derived from APP, and is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP) . N-APP binds TNFRSF21; this triggers caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6) . Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Tumor necrosis factor receptor superfamily member 21; Death receptor 6; CD358
Swiss Prot
O75509
Reactivity
Human
Immunogen
Recombinant protein of human CD358.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:2000~1:5000 IF 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 75 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD358 polyclonal antibody detects endogenous levels of CD358 protein.
Applications Notes
Western blot (WB) analysis of CD358 polyclonal antibody at 1:2000 dilution Lane1:EC9706 cell membrane lysate (30ug) Lane2:A549 whole cell lysate (30ug) Lane3:HepG2 whole cell lysate (30ug)
Host or Source
Rabbit

Related Products

CatalogName
NCP0307-01CD358 Recombinant Protein
NCP0306P-01CD357 polyclonal antibody
NCP0298P-01CD338 polyclonal antibody
NCP0392P-01CD318 polyclonal antibody
NCP0302P-01CD352 polyclonal antibody
BS62551-01CD354 polyclonal antibody
BS7288-01CD38 polyclonal antibody
BS90238CD38 polyclonal antibody
BS80063-01CD38 polyclonal antibody
BZ16794-01Polyclonal antibodyPN1 polyclonal antibody

Alternative Products

CatalogName
E43CP0307PCD358 polyclonal antibody
GWB-AAB969CD358 Antibody
abx140116CD358 Antibody (FITC)
ANT-11169-50ugCD358 / TNFRSF21 Monoclonal Antibody
E55A06125Human CD358/TNFRSF21 Antibody
HY-P990526Anti-TNFRSF21/DR6/CD358 Antibody
E55A06981Human CD358/TNFRSF21 Antibody , FITC
E55A07988Human CD358/TNFRSF21 Antibody , APC
E55A10002Human CD358/TNFRSF21 Antibody , PE
E55A08995Human CD358/TNFRSF21 Antibody , PerCP

Popular Products