CP-481715

CAT: 0804-HY-12079Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-12079Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

CP-481715 is a potent, reversible and selective CCR1 antagonist with a Kd of 9.2 nM for human CCR1. CP-481715 is >100-fold selective for CCR1 as compared with a panel of G-protein-coupled receptors including related chemokine receptors. CP-481715 has the potential for rheumatoid arthritis and other inflammatory diseases research[1].

CAS Number

212790-31-3

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

CCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cp-481715.html

Smiles

O=C(C1=NC2=CC=CC=C2N=C1)N[C@@H](CC3=CC=CC(F)=C3)[C@@H](O)C[C@H](C(N)=O)CCC(C)(O)C

Molecular Formula

C26H31FN4O4

Molecular Weight

482.55

Precautions

P261-P280-P302+P352

References & Citations

[1]Gladue RP, Tylaska LA, Brissette WH, Lira PD, Kath JC, Poss CS, Brown MF, Paradis TJ, Conklyn MJ, Ogborne KT, McGlynn MA, Lillie BM, DiRico AP, Mairs EN, McElroy EB, Martin WH, Stock IA, Shepard RM, Showell HJ, Neote K.CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases.J Biol Chem. 2003 Oct 17;278 (42) :40473-80. Epub 2003 Aug 7.|[2]Borregaard J, Skov L, Wang L, Ting N, Wang C, Beck LA, Sonne J, Clucas A.Evaluation of the effect of the specific CCR1 antagonist CP-481715 on the clinical and cellular responses observed following epicutaneous nickel challenge in human subjects.Contact Dermatitis. 2008 Oct;59 (4) :212-9.|[3]Gladue RP, Cole SH, Roach ML, Tylaska LA, Nelson RT, Shepard RM, McNeish JD, Ogborne KT, Neote KS.The human specific CCR1 antagonist CP-481,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice.J Immunol. 2006 Mar 1;176 (5) :3141-8.|[4]Ronald P Gladue, et al. CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases. J Biol Chem. 2003 Oct 17;278 (42) :40473-80.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CCR1

Related Products

Catalog	Name
HY-W879307	CP-201
HY-16373-01	CP-609754
HY-18343	CP-31398
HY-112199-01	CP-447697
HY-14130-01	CP 376395
HY-138879B-01	CP-601932
HY-169723	CP 524515
HY-122284	CP-5068
HY-12144-01	CP-99994
HY-111129	CP-66713

Alternative Products

Catalog	Name
TRC-C781405-100MG	CP-481715
521785-01	CP
2393690	Plate Set, CP CP-10
B2173-10	CP-673451
B5474-10	CP 20961
BA6819-1	CP-601932
BA6245-50	CP-312
A2412-5	CP-724714
A4435-10	CP 471474
BA7978-10	CP-346086

CP-481715

Related Products

Alternative Products

Popular Products