Ranitidine (bismuth citrate)

• UNSPSC Description:

  Ranitidine bismuth citrate is an orally active Histamine H2-receptor antagonist with an IC50 of 3.3 μM. Ranitidine bismuth citrate has high selectivity for SARS-CoV-2-infected cells. Ranitidine bismuth citrate is a commonly used agent anti-Helicobacter pylori infection with an MIC90 value of 16 ng/L[1][2][3].

• Target Antigen:

  Bacterial; Histamine Receptor; SARS-CoV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/ranitidine-bismuth-citrate.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=[N+](/C=C(NC)/NCCSCC1=CC=C(CN(C)C)O1)[O-].O=C(CC(C([O-])=O)(O)CC([O-])=O)[O-].[Bi+3]

• Molecular Weight:

  712.48

• References & Citations:

  [1]Herling AW, et al. Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions. 1987 Feb. 20(1-2):35-9.|[2]Yuan S, et al. Metallodrug ranitidine bismuth citrate suppresses SARS-CoV-2 replication and relieves virus-associated pneumonia in Syrian hamsters. Nat Microbiol. 2020 Nov. 5(11):1439-1448.|[3]Lambert JR, et al. The actions of bismuth in the treatment of Helicobacter pylori infection. Aliment Pharmacol Ther. 1997 Apr. 11(Suppl 1):27-33.|[4]Stables R, et al. Gastric anti-secretory, mucosal protective, anti-pepsin and anti-Helicobacter properties of ranitidine bismuth citrate. Aliment Pharmacol Ther. 1993 Jun. 7(3):237-46.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Launched

• CAS Number:

  128345-62-0