Ranitidine

• Description :

  Ranitidine is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine antagonizes Histamine (HY-B1204) -induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Ranitidine inhibits breast tumor development and spread in mice[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  Histamine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cancer; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/ranitidine.html

• Concentration :

  10mM

• Purity :

  99.9

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=[N+](/C=C(NC)/NCCSCC1=CC=C(CN(C)C)O1)[O-]

• Molecular Formula :

  C13H22N4O3S

• Molecular Weight :

  314.40

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Daly MJ, et al. Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br J Pharmacol. 1981 Jan;72 (1) :49-54.|[2]Vila-Leahey A, et al. Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice. Oncoimmunology. 2016 Mar 10;5 (7) :e1151591.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  H2 Receptor

• CAS Number :

  [66357-35-5]