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Ranitidine-d6 (hydrochloride)

CAT: 0804-HY-B0281ASSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0281ASSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ranitidine-d6 hydrochloride is the deuterium labeled Ranitidine hydrochloride. Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine hydrochloride antagonizes Histamine (HY-B1204) -induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Ranitidine hydrochloride inhibits breast tumor development and spread in mice[2][3].
CAS Number
1185238-09-8
UNSPSC
12352005
Target
Histamine Receptor; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling; Others
Field of Research
Cancer; Metabolic Disease
Purity
97.00
Solubility
H2O : 50 mg/mL (ultrasonic; warming)
Smiles
[2H]C([2H])([2H])N(C([2H])([2H])[2H])CC1=CC=C(CSCCN/C(NC)=C/[N+]([O-])=O)O1.Cl
Molecular Formula
C13H17D6ClN4O3S
Molecular Weight
356.90
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Vila-Leahey A, et al. Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice. Oncoimmunology. 2016 Mar 10;5 (7) :e1151591. |[3]Daly MJ, et al. Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br J Pharmacol. 1981 Jan;72 (1) :49-54.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
H2 Receptor

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