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Ranitidine (hydrochloride)

CAT: 0804-HY-B0281A-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0281A-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist that inhibits gastric secretion. Ranitidine hydrochloride antagonizes Histamine -induced increases of the guinea-pig isolated rat atrium and Histamine-induced relaxations of the rat isolated uterine horn, with pA2 values of 7.2 and 6.95, respectively. Ranitidine hydrochloride inhibits breast tumor development and spread in mice[1][2].
CAS Number
66357-59-3
UNSPSC
12352005
Hazard Statement
H315, H317, H319, H334, H335
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ranitidine-hydrochloride.html
Purity
99.86
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL
Smiles
CN/C(NCCSCC1=CC=C(CN(C)C)O1)=C\[N+]([O-])=O.Cl
Molecular Formula
C13H23ClN4O3S
Molecular Weight
350.86
Precautions
H315, H317, H319, H334, H335
References & Citations
[1]Daly MJ, et al. Some in vitro and in vivo actions of the new histamine H2-receptor antagonist, ranitidine. Br J Pharmacol. 1981 Jan;72 (1) :49-54.|[2]Vila-Leahey A, et al. Ranitidine modifies myeloid cell populations and inhibits breast tumor development and spread in mice. Oncoimmunology. 2016 Mar 10;5 (7) :e1151591.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H2 Receptor

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