Ranitidine (hydrochloride) (Standard)

Ranitidine (hydrochloride) (Standard)

• CAS Number: 66357-59-3
• UNSPSC Description: Ranitidine (hydrochloride) (Standard) is the analytical standard of Ranitidine (hydrochloride). This product is intended for research and analytical applications. Ranitidine hydrochloride is a potent, selective and orally active histamine H2-receptor antagonist with an IC50 of 3.3 μM that inhibits gastric secretion. Ranitidine hydrochloride is a weak inhibitor of CYP2C19 and CYP2C9[1][2].
• Target Antigen: Bacterial; Cytochrome P450; Histamine Receptor
• Type: Reference Standards
• Related Pathways: Anti-infection;GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Neuronal Signaling
• Field of Research: Infection; Endocrinology; Metabolic Disease; Cancer
• Assay Protocol: https://www.medchemexpress.com/ranitidine-hydrochloride-standard.html
• Smiles: CN/C(NCCSCC1=CC=C(CN(C)C)O1)=C\[N+]([O-])=O.Cl
• Molecular Weight: 350.86
• References & Citations: [1]Herling, A.W., et al., Inhibition of 14C-aminopyrine accumulation in isolated rabbit gastric glands by the H2-receptor antagonist HOE 760 (TZU-0460). Agents Actions, 1987. 20(1-2): p. 35-9.|[2]Leucuta, A., et al., A pharmacokinetic interaction study between omeprazole and the H2-receptor antagonist ranitidine. Drug Metabol Drug Interact, 2004. 20(4): p. 273-81.|[3] Antonio Francesco Ciccaglione, et al. Pylera® plus ranitidine vs Pylera® plus esomeprazole in first-line treatment of Helicobacter pylori infection: Two pilot studies. Helicobacter. 2019 Oct;24(5):e12606.
• Shipping Conditions: Room temperature